Amgen‘s Phase III MENDEL-2 trial with evolocumab met its co-primary endpoints: the percent reduction from baseline in low-density lipoprotein cholesterol (LDL-C) at week 12 and the mean percent reduction from baseline in LDL-C at weeks 10 and 12. The mean percent reductions in LDL-C, or “bad” cholesterol, compared to placebo and ezetimibe were consistent with results observed in the MENDEL Phase II study. Evolocumab is an investigational fully human monoclonal antibody that in...